In the world of pharmaceutical manufacturing, microcrystalline cellulose (MCC) is often called the “workhorse” of excipients.

However, not all MCC is created equal. While many suppliers provide an “average particle size,” experienced formulation scientists know that the real secret to tablet quality lies in Particle Size Distribution (PSD).

What is PSD and Why Should You Care?

Particle Size Distribution describes the spread of particle sizes within a batch. Instead of a single number, we look at the D10, D50, and D90 values.

• D10: 10% of the particles are smaller than this value. Too many fines can lead to “dusting” and poor flow.

• D50: The median particle size. This is what most people mean by “average.”

• D90: 90% of the particles are smaller than this. Large particles can affect the smoothness of the tablet surface.

The Impact on Your Production Line

1. Flowability: A consistent PSD ensures that the powder flows evenly into the tablet press, preventing weight variation between tablets.

2. Compressibility: The right mix of particle sizes allows for better interlocking during compression, resulting in optimal tablet hardness and lower friability.

3. Audit-Ready Quality: At SenoinfiTech, our MCC grades (like PH101 and PH102) undergo rigorous laser diffraction testing to ensure every batch meets your precise specifications.

Conclusion Choosing a supplier that understands the science of PSD is the first step toward formulation excellence.

Whether you are working on direct compression or wet granulation, SenoinfiTech provides the consistency you need to avoid production downtime and ensure consumer safety.